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The 49ers opened their week of preparation to face the Detroit Lions on Sunday with a lot of question marks. Wide receiver Marquise Goodwin had a deep thigh contusion and will likely be listed as questionable for the game, along with guards Mike Person (foot) and Joshua Garnett (toe), and linebacker Malcolm Smith (hamstring). Goodwin, Person and Garnett sustained injury in the season opener againt the Minnesota Vikings, while Smith has not played since the first preseason game.
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