Mount St. Mary's vs Duke Prediction: Odds, Expert Picks, Betting Trends and Stats for 2025 March Madness

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The Duke Blue Devils (31-3), the No. 1 seed in the East Region face the Mount St. Mary's Mountaineers (23-12), the No. 16 seed, in the first round of the NCAA Tournament on Friday in Raleigh, NC.

Under coach Jon Scheyer, Duke won the ACC regular season and tournament. The team boasts a stacked roster led by star freshman Cooper Flagg, the presumptive No. 1 NBA Draft pick. Flagg is expected to return from a sprained ankle suffered during the ACC Tournament.


The Mountaineers, led by coach Dan Engelstad earned their tournament berth by winning the MAAC Championship followed by a win in their First Four game against American University, 83-72, Wednesday night. Dola Adebayo leads the Mountaineers in scoring averaging 13.4 points per game.


It would be shocking if Duke's aggressive defense and fast-paced offense do not combine to overwhelm the Mountaineers.


The winner of this game earns the right to play the winner of the Mississippi State vs. Baylor game Sunday.


Lets dive into the matchup and offer some information and possibly a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the opening tip, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.


Game details & how to watch Mount St. Mary’s vs. Duke

  • Date: Friday, March 21, 2025
  • Time: 2:50PM EST
  • Site: PNC Arena
  • City: Raleigh, NC
  • Network/Streaming:

Never miss a second of the action and stay up to date with all the latest scores and player news. Check out our day-by-dayNCAA Basketball Schedule Page that includes live game updates.


Game odds for Mount St. Mary’s vs. Duke


The latest odds as of Thursday courtesy of BetMGM:

  • Odds: Mount St. Mary's Mountaineers , Duke Blue Devils (
  • Spread: Blue Devils 0
  • Total: points

Expert picks & predictions for Mount St. Mary’s vs. Duke



NBC Sports Bet Best Bet​



Our model calculates projections around each moneyline, spread and over/under bet for every game on the NCAA calendar based on data points like past performance, player matchups, injuries, and the schedule.


Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday’s Mountaineers & Blue Devils game:


  • Moneyline: This game is not offered on the Moneytline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Duke Blue Devils -32.5.
  • Total: NBC Sports Bet is leaning towards a play on the Game Total OVER 140.5.


Mount St. Mary’s vs. Duke: Top betting trends and recent stats



  • Duke is riding an 11-game winning streak
  • Duke is 8-3 against the spread in their last 11 games (21-10 ATS for the season)
  • Over their last 11 games, Duke's Game Totals are 7-4 to the OVER
  • Mount St. Mary's has won 6 of their last 7 games on the Moneyline
  • Mount St. Mary's is 7-0 against the spread in their last 7 games (18-11 ATS for the season)

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out ourNCAA Basketball Top Trends Toolon NBCSports.com!


Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.



Follow our experts on socials to keep up with all the latest content from the staff:
· Jay Croucher (@croucherJD)
· Drew Dinsick (@whale_capper)
· Vaughn Dalzell (@VmoneySports)
· Brad Thomas (@MrBradThomas)

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