footballguys.com's Joe Bryant sees it this way:
Arizona's Passing Attack vs. The Detroit Defense (Tough Matchup)
Rookie John Navarre gets his first NFL start at QB after holding a clipboard as the third-stringer for most of the regular season (and training camp before that). The teams' best running back, Emmitt Smith, is not expected to be able to play, further increasing the pressure on the rookie. This is not the week to expect big numbers from Boldin/Fitzgerald/Johnson. And that's all we have to say about that.
However, if interceptions count for a lot of points in your IDP league, this is probably a great week to start CBs Dre' Bly and Fernando Bryant or Ss Brock Marion (FS) and Bracy Walker (SS) if they are on your roster. Detroit deploys a pretty forgiving secondary, ranking 22nd in the NFL this season allowing an average of 225.2 passing yards per game, with 22 TDs given away in this phase of the game to date (tied for 3rd-most in the NFL). Over the past 4 weeks, they've been allowing less yards most of the time (176 on average), but still give up points (2.8 passing scores per game). Peyton Manning crushed these guys last week, hitting Detroit for 23/28 for 236 yards and 6 TDs.
Neither team has injuries of note to worry about in this matchup.
This game is to be played at Ford Field – weather won't be a factor.
Inserting a rookie into this situation is asking an awful lot of the youngster – most veterans would have a hard time with Smith out and so few reps over the season to keep the rust off their arm. This is a tough matchup for Navarre, due to the fact that the Lions won't have to respect the run and will most likely blitz him unmercifully.