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4) Arizona Cardinals
OLB John Abraham, concussions, IR
DE Darnell Dockett, knee, IR
This is why Todd Bowles is the frontrunner for Defensive Coordinator of the Year (too bad that award doesn’t exist). Abraham was the team’s only viable edge-rusher up front, while Dockett’s violent hands and tenacity made him ideal in Arizona’s hybrid 3-4 system. The Cardinals have survived both losses because their secondary can play tight man-to-man across the board, allowing Bowles to still use his myriad blitz packages.
It’s possible that Carson Palmer will also soon be added to this list.
http://mmqb.si.com/2014/09/24/nfl-injuries/
No surprise about the #1 team. I can't remember the last time that a team lost its #1, #2 and #3 RBs before even week 5. And that's on top of many, many other significant injuries to other positions.
Cards were hit hard by injuries/suspensions before the season even began.