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Keith Appling scored a career-high 25 points and sparked a 20-0 second-half run to help No. 16 Michigan State hand No. 13 Indiana its first loss of the season, 80-65 on Wednesday night. Appling, who had 18 points in the second half, added seven assists for the Spartans (12-2, 1-0 Big Ten), winners of 12 straight.
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