Everyone locally is worried about LT Trent Williams. He didn't do anything in camp and had to have TWO IV's during the first game as a result of fatigue. I think the 49ers assumed he could rest and be fine for the season, they even extended him to free up caproom, but first week he was exhausted and had to get the IV's, last week he had the worst game of his 49er career, gave up a sack, 3 near miss sacks.
With the injuries to CMC and Deebo the offense is short handed so they really want to be able to run the ball and rely on the defense, so they need Williams to step it up and nobody is quite sure yet if he still can or if he's too old