Please no. A big like Stoudemire would be ok i guess,as long as we dont pair him with an equally defensively inept PG and decide to build around that (again).
Bottom line for me is that I really dont think its a good idea to build around multiple players that can't guard people and make that your core group.
There's definately a place for guys like that on good teams(players that are defensive liabilities),but i'd prefer to draft players that are well-rounded.
IMO your starting 5 should all be guys that wont kill you dfensively(of course you're going to need a couple of pure scorer's too...but they cant be awful defensively). Then you can bring your role players off the bench,guys that maybe are one-dimensional liabilities either offensively or dfensively etc...