Sure it can be done...Chicago does that very well. Unfortunately for you guys your defense isn't as talented. If they try to go for the strip, while thinking about how Gore has a bad hand...they will get run over or around by Frank.
If they're smart they'll wrap up and make sure he can't get extra yards.
But hey I wish they do go for the strip...that means only one arm is trying to bring him down.
Wasn't fumbling a problem for him before he broke his hand? I think he is a stud running back, but outside of unproven vernon davis, your offense has no one to fear. I would think they would lighten the load on gore, because if he goes down, so does your season.