Im not worried about Lance specifically...more in the run game in general. When the 49ers are able to run the ball and stick to their game plan they are a tough team to beat.
If we are able to shut down the run like we did against the Titans...but not again since....then I think we can win the game easily.
If we don't contain the run, I think this game is close, and I worry about us coming out flat and losing a very winnable game.
Bottom line is that we are hot, San Fran is missing a lot of key guys, and we need to win this divisional game one way or another. Good/Great teams who are legit playoff threats don't waste an opportunity to pick up a divisional win against a wounded opponent. I dont care if it's 49-42 or 3-0...we need this win. The Browns the following week means we could easily be on a 2 game losing streak, losing all of this momentum we have gained, if we don't come out and take control.