Obviously it's not the difference in the game but if they did what the NFL apparently thinks they did, they better nail them on draft picks again. Apparently the NFL thinks the Pats had properly inflated balls, and under inflated balls, on their sideline. When they were on offense, they used the properly inflated ball, when they were on defense, they used the under inflated ball. Apparently the home team controls the balls from the sideline and they were able to just give the ref the good ball for them and the flat ball for the Colts.
Apparently Andrew Luck complained early in the game the ball was under inflated and eventually at halftime the coaching staff confronted the refs, and they at some point in the game pulled out at least one and maybe 2 balls that had been put in play, so they could weigh them.
They can't forfeit the game and with that one sided a game wouldnt' be fair, but they can take draft picks from the Patriots.