This is like how we heard for almost 20 years the Cardinals had a big advantage at SDS because of the heat. They obviously didn't. Or that Green Bay is almost unbeatable in extreme cold. False. In the modern era, their record is worse in extreme cold than their averages at higher temperatures.
All time record at home:
Denver Nuggets .652
Phoenix Suns .656
Portland Blazers .664
Those are the only three teams I looked at. Portland's elevation is '50. Higher elevation is not a huge advantage for Denver. Never has been, never will be.
It's only playing basketball for a couple of hours. These guys have done that forever, every day almost. Many days, a lot more than 2 hours. This is why I don't worry about minutes that much either. The worst thing about more minutes is, statisically, you are more likely to get injured. Not because of more minutes, but because of more opportunity. If the player is so exhausted, it's first of all on the PLAYER to take themselves out. Then on the coach.