Probably, but I wouldn't rule out the Sandman or the Vulture. I could see Lowell playing both of them, too. The Sandman would look pretty sweet on the big screen, IMO.Brian in Mesa said::venom:
But, yeah, probably Venom. It's sort of the worst kept secret in Hollywood. Everyone is talking not only about Venom, but how he's introduced (through JJJ's son's space expidition).
One of the reasons I don't like having Venom in #3 is that he's not a "classic" Spidey villain. I'd like to see them run through the originals before they get into some of the more modern bad guys.
....here's another thought: he could also play the Chameleon.