So how will they fit together? Hopkins will generally line up out wide on one side of Murray while Green will be wide on the other, a position that Gruden said fits Green perfectly because of his size, length and strength.
One of the first things Green and Hopkins talked about after Green signed in March was their alignments. Hopkins told Green: "If you want a route and I'm on that side, we can switch."
And they don't have to run it by Cardinals coach Kliff Kingsbury, who calls the offense's plays.
"Whoever's running a route between A.J. Green and DeAndre Hopkins, I'm going to be happy with," Kingsbury said.
"This offense fits me to a T, because that's what I'm used to," Green said. "When I first came into the league with Jay Gruden, a lot of big posts, a lot of different outside routes. That was my bread and butter. In the last couple of years, that wasn't the case."
Already in practice, Jefferson has seen when the coverage has rolled toward Hopkins, Green has made plays deep and over the top.
"If they want to play one-on-one coverage on them," Jefferson said, "God bless them."
Neither Hopkins nor Green has played alongside a receiver like the other. If they can stay healthy, it could be a "big issue" for opposing defenses.
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